The Cell: A Molecular Approach

Fourth Edition

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Chapter 5: The Organization and Sequences of Cellular Genomes

Micrograph 5.2  Structure of Metaphase Chromosomes

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An electron micrograph of DNA loops attached to the protein scaffold of metaphase chromosomes that have been depleted of histones. [From J.R. Paulson and U.K. Laemmli, 1977. Cell 12: 817.]