Immunity: The Immune Response in Infectious and Inflammatory Disease

Anthony L. DeFranco, Richard M. Locksley, and Miranda Robertson

2007
387 pages, 367 illustrations
paper

About the Book

Published by New Science Press and distributed in the U.S. and Canada by Sinauer Associates

Immunity is an introduction for undergraduates and medical students to the immune response to infection. Chapter 1 provides an overview of the immune mechanisms of innate and adaptive immunity, cells of the immune system, and the lymphoid system and lymphocyte recirculation. Chapter 2 introduces the major molecular families that direct and regulate immune responses. This chapter provides background for more detailed accounts to follow, beginning with a major chapter on innate immunity that allows the later chapters on the activation and effector actions of lymphocytes to illustrate how adaptive immune responses are built on innate mechanisms. These are followed by chapters on the development of the lymphocyte repertoire and on specialized lymphocytes with roles intermediate between innate and adaptive immunity, with chapters on the immune response to specific microorganisms that illustrate how the mechanisms described in earlier chapters are coordinated in response to some important human pathogens. The book concludes with chapters on immune regulation and immunological disease, succinctly covering the most clinically important hyperreactive and deficiency diseases and the design of vaccines.

Immunity is distributed outside the U.S. and Canada by Oxford University Press. Contact information is as follows:

Oxford University Press
Saxon Way West
Corby, Northants
NN18 9ES
United Kingdom
Telephone: +44 (0)1536 741727
Fax: +44 (0)1536 746337
E-mail (orders): bookorders.uk@oup.com
E-mail (queries): bookquery.uk@oup.com

Customers in the UK may use the OUP freepost address:
Oxford University Press
FREEPOST NH 4051
Corby, Northants NN18 9BR

About the Authors

Anthony L. DeFranco graduated from Harvard University in biochemistry and molecular biology in 1975. He did his Ph.D. on bacterial chemotaxis with Daniel E. Koshland, Jr. at the University of California at Berkeley before turning to his present principal research interest, the activation of B lymphocytes, as a postdoctoral worker in the laboratory of William E. Paul at NIH in 1979. He is currently Chairman of the Department of Microbiology and Immunology at the University of California San Francisco Medical School, where his research interests are the mechanisms of signaling by the B cell antigen receptor and Toll-like receptors, and B cell autoimmunity.

Richard M. Locksley graduated from Harvard University in Biochemistry in 1970 and in Medicine from the University of Rochester in 1976. He was at the Moffitt Hospital in San Francisco for four years as a Medical Resident, trained in infectious diseases at the University of Washington for three years, and then returned to the University of California in San Francisco where he served as Chief of the Division of Infectious Diseases from 1986–2004. He is currently the Sandler Distinguished Professor of Medicine and Microbiology and Immunity, Director of the Sandler Asthma Basic Research Center, and an HHMI Invertigator at UCSF. The principal focus of his research is on cellular immune responses in infectious and inflammatory disease.

Miranda Robertson studied psychology at Birkbeck College London and at the University of Chicago in the 1960s without graduating from either, and then spent the greater part of a quarter-century on the editorial staff of Nature, ultimately as its Biology Editor. Since then, she has worked on behalf of Garland Publishing, Inc. and Current Biology, Ltd. with the authors of several outstanding textbooks. She is now the Managing Director of New Science Press, Ltd.

Reviews and Commentary

“The modular packaging of material into easily digestible bite-size nuggets makes this an excellent book that is both informative and fun to read. … this is a highly readable publication that admirably serves a dual role of both a textbook and reference.”
—James D. Gorham, The Quarterly Review of Biology

Download a PDF of the complete contents

Click any highlighted section to view PDFs of pages from that section.

1. Overview of the Immune Response
1-0 Overview: The Protective Mechanisms of Immunity
1-1 Cells of the Immune System: Differentiation in the Bone Marrow
1-2 Cells of the Immune System: Functional Characteristics
1-3 Macrophage and Dendritic Cell Subsets
1-4 Clonal Selection of Antigen-Specific Lymphocytes
1-5 Major Histocompatibility Molecules and the Detection of Infection
1-6 The Lymphoid System and Lymphocyte Circulation
1-7 Architecture of Secondary Lymphoid Tissues
1-8 The Course of an Immune Response

2. Signaling and Adhesive Molecules of the Immune System
2-0 Overview: Immune Cell Surface and Signaling Molecules
2-1 The Immunoglobulin Superfamily: Structural Features
2-2 Signaling by Immunoglobulin Superfamily Receptors
2-3 Adhesion Molecules of the Immunoglobulin Superfamily
2-4 Integrins in Immune Function
2-5 C-Type Lectins and Carbohydrate Recognition
2-6 Cytokines and Cytokine Receptors
2-7 Cytokine Receptors that Signal via the Jak–STAT Pathway
2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
2-9 The TNF Superfamily of Cell Regulators
2-10 NF-kB and Inflammatory Cytokine Action
2-11 Molecular Control of Apoptosis
2-12 Regulation of Apoptosis by Bcl-2 Family Members
2-13 Chemokines and Chemokine Receptors
2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

3. Innate Immunity
3-0 Overview: Evolution and Function of Innate Immunity
3-1 Barriers to Infection at the Epithelium
3-2 Innate Recognition by Soluble Collectins and Ficolins
3-3 Overview of the Complement System
3-4 Activation of the Complement Cascade
3-5 Complement Effector Actions and Receptors
3-6 Regulation of Complement and Evasion by Microbes
3-7 Recognition of Microbes by Phagocytes
3-8 Mechanisms of Phagocytosis
3-9 Destructive Mechanisms of Phagocytes
3-10 The Toll-Like Receptor Family of Innate Immune Receptors
3-11 Toll-Like Receptor Signaling to Cytokine Production
3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
3-13 Inflammation: Initiation of an Inflammatory Response
3-14 Inflammation: Recruitment of Immune Cells
3-15 Inflammation: Regulation and Systemic Effects
3-16 Innate Defense Against Viruses: Interferon
3-17 Inhibition of Virus Replication by Interferon
3-18 Innate Defense Against Viruses: Induction of Apoptosis
3-19 Intracellular Defenses Targeting Viral Nucleic Acid

4. Adaptive Immunity and the Detection of Infection by T Lymphocytes
4-0 Overview: The Role of T Cells in the Adaptive Immune Response
4-1 Dendritic Cells in the Induction of Adaptive Immunity
4-2 The Structure and Function of MHC Molecules
4-3 The MHC and Polymorphism of MHC Molecules
4-4 Non-Classical MHC Class I Molecules
4-5 Peptide Binding by MHC Molecules
4-6 Antigen Presentation by Classical MHC Class I Molecules
4-7 Antigen Presentation by MHC Class II Molecules
4-8 Regulation of Antigen Presentation
4-9 Specialized Features of Antigen Presentation by Dendritic Cells

5. Activation and Effector Actions of T Cells
5-0 Overview: T Cell-Mediated Immune Responses
5-1 Antigen Recognition by T Cells: Structure of the Receptor
5-2 Antigen Recognition by T Cells: TCR Specificity and Coreceptors
5-3 Signaling from the T Cell Receptor
5-4 Regulation of TCR Signaling
5-5 T Cell Signaling to the Nucleus and the Role of CD28
5-6 Activation of Naïve T Cells in Secondary Lymphoid Tissue
5-7 Clonal Expansion of Naïve T Cells in Secondary Lymphoid Tissue
5-8 Costimulatory Signals in T Cell Proliferation and Survival
5-9 Effector T Cell Differentiation
5-10 The Polarization of T_H1 and T_H2 Cells
5-11 The Functions of T_H1 Cells
5-12 The Functions of T_H2 Cells
5-13 The Functions of T_FH Cells, T_H17 Cells and Induced T_REG Cells
5-14 Effector Functions of CD8 T Cells
5-15 T Cell Homeostasis and the Termination of Immune Responses
5-16 T Cell Memory

6. B Cells and Humoral Immunity
6-0 B Cells and the Importance of Antibodies for Immune Defense
6-1 Structure of Antibodies
6-2 Structural Properties of Antibodies
6-3 Effector Functions of Antibodies
6-4 Monoclonal Antibodies
6-5 Antibody-Based Methods: Radioimmunoassay and Hemagglutination
6-6 Antibody-Based Methods: ELISA, Immunoblotting and FACS
6-7 Antigen Receptors of B Lymphocytes
6-8 B Cell Antigen Receptor Signaling and B Cell Coreceptors
6-9 Early and T Cell-Independent Responses by B Cells
6-10 Initiation of T Cell-Dependent Antibody Responses
6-11 Hypermutation and Isotype Switching in the Germinal Center
6-12 Selection and Differentiation of B Cells in the Germinal Center

7. Development of Lymphocytes and Selection of the Receptor Repertoire
7-0 Overview of Lymphocyte Development
7-1 Antigen Receptor Gene Structure and V(D)J Recombination
7-2 V(D)J Recombination: Mechanism of Recombination
7-3 V(D)J Recombination: Control of which Segments Recombine
7-4 Phylogenetic Diversity in Antigen Receptor Genes
7-5 B Cell Development in the Bone Marrow
7-6 Maturation of B Cells in the Periphery
7-7 Organization of the Thymus and Early T Cell Development
7-8 Positive Selection of T Cells in the Thymus
7-9 Proposed Mechanisms of Positive Selection
7-10 Negative Selection
7-11 Diseases Related to Lymphocyte Development

8. Specialized Lymphocytes in Early Responses and Homeostasis
8-0 Overview: Specialized Lymphocyte Populations
8-1 Natural Killer Cells and their Role in Immunity
8-2 Natural Killer Cell Signaling Pathways
8-3 NKT Cells
8-4 γδ T Cells
8-5 Intraepithelial Lymphocytes and Other Specialized T Cells
8-6 B1 Cells
8-7 Marginal Zone B Cells

9. The Immune Response to Bacterial Infection
9-0 Overview: Bacterial Pathogens and Host Defenses
9-1 Epithelial Barriers and Defenses against Infection
9-2 Evasion of Epithelial Defenses by Pathogenic Bacteria
9-3 Sepsis Syndrome: Bacterial Endotoxin
9-4 Sepsis Syndrome: Bacterial Superantigens
9-5 The Immune Response to Streptococcus pneumoniae
9-6 Listeria monocytogenes
9-7 Mycobacterium tuberculosis

10. The Immune Response to Viral Infection
10-0 Overview: Viral Infectious Strategies
10-1 Overview: Innate Strategies Against Viruses
10-2 Overview: Adaptive Immune Strategies Against Viruses
10-3 Subversion of Immune Mechanisms by Viruses
10-4 Origin and Structure of Human Immunodeficiency Virus
10-5 Tropism of Human Immunodeficiency Virus
10-6 AIDS Progression and Immune Control of HIV
10-7 Influenza Virus: Antigenic Shift and Drift
10-8 Influenza Virus: Innate and Adaptive Immunity
10-9 Lymphocytic Choriomeningitis Virus (LCMV)

11. The Immune Response to Fungal and Parasitic Infection
11-0 Overview: The Scope of Fungal and Parasitic Infections
11-1 Candida albicans
11-2 Pneumocystis
11-3 Leishmania major
11-4 Nippostrongylus brasiliensis
11-5 Schistosomiasis

12. Tolerance and Autoimmunity
12-0 Overview: Tolerance and Autoimmunity
12-1 Central Tolerance
12-2 Peripheral Tolerance Mechanisms
12-3 Regulatory T Cells
12-4 Autoimmune Diseases: General Principles
12-5 Organ-Specific Autoimmunity: Antibody-Mediated Diseases
12-6 Organ-Specific Autoimmunity: Cell-Mediated Diseases
12-7 Organ-Specific Autoimmunity: Animal Models
12-8 Systemic Autoimmunity: Lupus
12-9 Systemic Autoimmunity: Rheumatoid Arthritis

13. Allergy and Hypersensitivity
13-0 Overview: Causes and Nature of Hypersensitivity Reactions
13-1 Mast Cells and Allergic Reactions
13-2 Allergic Diseases
13-3 Asthma
13-4 IgG-Mediated Immune Pathology
13-5 Delayed-Type Hypersensitivity Reactions
13-6 Inflammatory Bowel Disease

14. Transplantation Immunology, Tumor Immunity and Vaccination
14-0 Overview: Boosting and Suppressing Immune Responses
14-1 Immunodeficiencies
14-2 Features of Successful Vaccines
14-3 Engineering Vaccines for Safety and Efficacy
14-4 Vaccines for Chronic Infections and Cancer
14-5 Tumor Immunity
14-6 Transplants and Transplantation Antigens
14-7 Transplant Recognition and Rejection
14-8 Immunosuppression of Transplant Recipients

Glossary
References
Index

Media and Supplements

FOR THE INSTRUCTOR

All of the illustrations from the book, self-assessment questions, and videos of leading immunologists are freely available at:

http://www.oup.com/uk/orc/bin/9780199206148/

Pricing and Options

Titles	Product Code	Price (USD)
Immunity: The Immune Response in Infectious and Inflammatory Disease	978-0-87893-179-8	$57.95	Purchase	Request Exam Copy
View Cart
Outside the U.S., Canada, or the Caribbean? Check our ordering page for local distributors.

Home || Contact Us || About Ordering || List by Author
List by Subject Area || List by Title || View Shopping Cart

Title Information

Related subject areas

Catalog