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Genetics and Analysis of Quantitative Traits
Michael Lynch, Indiana University at Bloomington, and Bruce Walsh, University of Arizona
1998
980 pages, 245 illustrations
casebound
About This Title
With the emerging recognition that the expression of most characters is influenced by multiple genes and multiple environmental factors, quantitative genetics has become the central paradigm for the analysis of phenotypic variation and evolution.
Genetics and Analysis of Quantitative Traits brings together the diverse array of theoretical and empirical applications of quantitative genetics under one cover, in a way that is both comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics. What was originally envisioned as a single text has now become two, with the focus of this first book being on the basic biology and methods of analysis of quantitative characters. (The second book, Evolution and Selection of Quantitative Traits, will address the basic principles that govern the evolutionary dynamics of quantitative characters under the forces of mutation, random genetic drift, and natural and/or artificial selection, integrating the theory of evolution of such characters with existing empirical data from natural and domesticated plant and animal populations.) Written as a general text in quantitative genetics, the book will also be useful as a basic reference for the seasoned professional. Throughout, central theoretical concepts are developed from first principles. To aid the less statistically sophisticated reader, several chapters and appendices focus on the basic statistical tools needed to digest the book. Wherever possible, theoretical and analytical concepts are illustrated with empirical examples from diverse settings.
Three major features of Genetics and Analysis of Quantitative Traits distinguish it from earlier work. First, it reflects the explosive influx over the past few years of quantitative-genetic thinking into evolutionary biology. Second, in animal breeding, enormous strides have been made in the development of new techniques for estimating breeding values (for the purposes of identifying elite individuals in selection programs) and for estimating variance components from samples of complex pedigrees. In this text's last two chapters, the authors outline the basic principles of complex pedigree analysis, without getting bogged down in technical details. Third, Genetics and Analysis of Quantitative Traits provides a broad overview of the newly emerging array of techniques for quantitative-trait loci (QTL) analysis, currently one of the most active fields of quantitative-genetic research.
Genetics and Analysis of Quantitative Traits contains numerous fully-worked examples and illustrations of theoretical concepts, as well as over 2,000 references with indices by subject, author, and organism. In addition, the authors maintain a World Wide Web site featuring up-to-date lists of computer programs and on-line resources, and added information on various topics presented in the text.
Reviews and Commentary
“ . . . I have nothing but the highest praise for this book, which will surely stand as the definitive treatment for many years to come. The content is comprehensive, the writing clear and concise, indeed elegant, and the overall impression is of a masterly tour de force.”
—Warren J. Ewens, American Journal of Human Biology
"This important and useful book will have a permanent place on my desktop . . . . Not only is this an essential reference book, but it is also an excellent textbook."
—Christopher J. Basten, Theoretical Population Biology
Table of Contents
I. The Genetic Basis of Quantitative Variation
1. An Overview of Quantitative Genetics
2. Properties of Distributions
3. Covariance, Regression, and Correlation
4. Properties of Single Loci
5. Sources of Genetic Variation for Multilocus Traits
6. Sources of Environmental Variation
7. Resemblance between Relatives
8. Introduction to Matrix Algebra and Linear Models
9. Analysis of Line Crosses
10. Inbreeding Depression
11. Matters of Scale
II. Quantitative-Trait Loci
12. Polygenes and Polygenic Mutation
13. Detecting Major Genes
14. Basic Concepts of Marker-Based Analysis
15. Mapping and Characterizing QTLs: Inbred-Line Crosses
16. Mapping and Characterizing QTLs: Outbred Populations
III. Estimation Procedures
17. Parent-Offspring Regression
18. Sib Analysis
19. Twins and Clones
20. Cross-Classified Designs
21. Correlations Between Characters
22. Genotype x Environment Interaction
23. Maternal Effects
24. Sex Linkage and Sexual Dimorphism
25. Threshold Characters
26. Estimation of Breeding Values
27. Variance-Component Estimation with Complex Pedigrees
Appendices
1. Expectations, Variances and Covariances of Compound Variables
2. Path Analysis
3. Matrix Algebra and Linear Models
4. Maximum Likelihood Estimation and Likelihood-Ratio Tests
5. Estimation of Power of Statistical Tests
Pricing and Options
| Titles | Product Code | Price (USD) | ||
|---|---|---|---|---|
|
Genetics and Analysis of Quantitative Traits | 0-87893-481-2 | $101.95 | Purchase | Request Exam Copy |
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